UCSF maps 1,800 protein interactions across 100 autism genes

The decade-long project found 87% of those interactions were unknown, aiming drugs at shared molecular interfaces instead of each gene.

Researchers screened 100 high-confidence autism genes, far more than earlier studies covering only a handful.
The Krogan, Willsey and State labs built this atlas over more than a decade of work.
The map targets molecular interfaces instead of genes, a blueprint that also fits cancer and neurodegeneration.

Why it matters: A hundred genes converging on shared molecular chokepoints means autism was never as scattered as it seemed.

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